Since vice versa, iron deficiency and inflammatory cytokines increase FGF23 production in bone (53), FGF23 could be part of a vicious cycle that contributes to FGF23-driven pathologies associated with CKD, such as anemia and systemic inflammation (62, 203), which are also potent inducers of pathologic cardiac remodeling and injury (199). The gene discussed is FGF23; the disease is anemia (phenotype).