It is possible that classic factors associated with mineral metabolism [such as phosphate, calcium 1,25D, and PTH (11, 49–52)] and novel factors linked to pathologic scenarios [such as systemic elevations of inflammatory cytokines, iron deficiency, and hypoxia (53–56)] regulate FGF23 production in osteocytes and osteoblasts at different levels. This evidence concerns the gene FGF23 and nutritional disorder.