In GBM cells treated with artocarpin, mitochondrial-mediated apoptosis was regulated by antiapoptotic (Bcl-2, Bcl-Xl, Bcl-1) and proapoptotic (Bax, Bad, and Bak) proteins (Savitskaya and Onishchenko, 2015). This evidence concerns the gene BAK1 and glioblastoma.