The multivariate logistic regression analysis of ITGA4 genotypes in the APOE-ε4-negative group adjusted for gender and age revealed no changes in comparison with the univariate analysis, and thus, the significantly higher prevalence of +3061AG carriers in AD patients compared to the controls was preserved (AA + GG versus AG, P = 0.008, OR = 2.26, Table 4). This evidence concerns the gene ITGA4 and Alzheimer disease.