On the other hand, genotyping in APOE-ε4-negative individuals showed significantly higher prevalence of +3061AG genotype in AD patients compared to the controls in the codominant genetic model (AG versus GG, P = 0.012, OR = 2.49), dominant genetic model (AG + GG versus AA, P = 0.007, OR = 2.23) and overdominant model (AA + GG versus AG, P = 0.003, OR = 2.40) as shown in Table 4. This evidence concerns the gene APOE and Alzheimer disease.