Wang et al. reported that UBXN1 is induced in a late step of viral infection, and negatively regulates RIG-I-like receptor signaling, interacting with the TRAF 3/6-binding site in MAVS through its N-terminal UBA domain as a dominant-negative binder, and thus disrupting MAVS–MAVS aggregation30. This evidence concerns the gene UBXN1 and viral infectious disease.