CCL2 and obesity due to melanocortin 4 receptor deficiency: However, the analysis in our independent cohort suggested that miR-374a-5p may modulate CCL2 expression, a pro-inflammatory biomarker, that is upstream in the pathway that leads to dyslipidaemia in obesity; thus, inflammation could be one of the driver of the change seen in lipid profile in obesity-related co-morbidities.