Although the percentages of cells with CD4, CD8, CD3, CD19 and CD56 were within the normal reference range for Chinese patients79,80, serum levels of 25(OH)D3 and 25(OH)D2 were significantly correlated with three or more immune markers in CRVD, CAD, T2DM and hypertension patients (Table 2). Here, CD8A is linked to type 2 diabetes mellitus.