The clear trends in the CD4, CD8 and CD4/CD8 data suggested the induction of a Th1 immune marker profile in hypertension patients, with a greater proportion of CD8-positive cells observed in 25(OH)D3-deficient patients (<20 ng/mL), and a greater proportion of CD4-positive cells observed in patients with serum 25(OH)D3 >20 ng/mL. The gene discussed is CD4; the disease is hypertensive disorder.