Several groups have reported an elevation of IL-31 in skin from patients with atopic dermatitis, in bronchoalveolar lavage fluid from patients with allergic asthma, and rhinitis; in intestinal mucosa from patients with inflammatory bowel disease; and recently in sera and aqueous humour from patients with acute anterior uveitis associated with HLA-B27 and osteoporosis27,34,35,38–44. Here, IL31 is linked to inflammatory bowel disease.