AIF1 and central nervous system cancer: Interestingly, we report similar effects in vivo: when glioma-bearing mice were treated with PAP-1 as described above, infiltration of the tumor mass by microglia and other myeloid (Iba-1+) cells was markedly reduced (Fig. 4c), confirming the crucial role of Kv1.3 in mediating glioma-induced myeloid cell migration.