C57BL/6 mice were inoculated with 1 × 105 B16F10 melanoma cells on day 0 and treated intraperitoneally (IP) with IL-15 (2 μg/mouse) or P22339 (5 μg/mouse and 15 μg/mouse) at days 1, 2, and 10. This evidence concerns the gene IL15 and melanoma.