NOTCH4 and adenocarcinoma: Vasculogenesis-associated genes including neurogenic locus notch homolog protein 4 (NOTCH4) and transforming growth factor beta receptor 3 (TGFBR3) expression were significantly downregulated in adenocarcinoma tissue versus normal tissue (adjusted p < 0.001 for NOTCH4 and adjusted p < 0.001 for TGFBR3) (Fig. 3b).