We compared the expression stability of 11 ERE sequences and 8 commonly used reference genes in a diverse set of experimental set-ups, including different organs of healthy adult mice, heart tissue of wild-type and Fbn1 mutant mice presenting cardiomyopathy, normal versus tumor tissue of three different transgenic mouse models (K14-Snail, LSL-MYCN;LSL-ALKF1174L;ETV5loxP/loxP; DBHiCre, and Zeb2), and in multipotent neural crest progenitor JoMa1 cell lines. The gene discussed is MYCN; the disease is cardiomyopathy.