LPA and metabolic syndrome: For example, in the Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides and Impact on Global Health Outcomes (AIM-HIGH) study, patients who achieved LDL-C levels of 1.69 mmol/L and had Lp(a) levels of >500 mg/L had an 89% higher risk of MACEs compared with those who had similar LDL-C, but low Lp(a) levels25.