It was also reported that CYP1A1 (cytochrome P450 1 A 1) protein expression was decreased in methionine-choline- deficient-diet-induced NAFLD mice and that 3,3′-diindolylmethane significantly up-regulated the protein expression of CYP1A1, which could be used as a potential therapeutic candidate for NAFLD37. This evidence concerns the gene CYP1A1 and metabolic dysfunction-associated steatotic liver disease.