TF and cancer: In cultured cancer cells, TF binding motifs were only enriched (one-sided Fisher’s exact test Q-value < 0.05) in peaks with sensitive width (78 motifs enriched in sensitive width compared to 1 for robust area, 2 for robust width, and 0 for all other peak sets, Fig. 3c, Supplementary Fig. 5a), while in mouse liver TF binding motifs were only enriched in peaks with robust width (249 motifs enriched in robust width compared to 0 for all other peak sets, Fig. 3d, Supplementary Fig. 5b).