INS and type 2 diabetes mellitus: When summarizing the results of our data and analysis, we are able to characterize our four adiposity genetics classes with regard to anthropometry, fat depots, metabolic consequences, and implicated pathways (Supplementary Table 2): (i) BMI + WHR + alleles increased waist, hip, SAT, VAT as well as T2D and CAD risk consistent with the observed adverse lipids and insulin profile.