The co-associations on T2D and CAD (Fig. 4d) showed a clear pattern for increasing or decreasing disease risk for the two “extreme” classes BMI + WHR + or BMI + WHR−, respectively, but a rather neutral or inconclusive pattern for BMIonly + (except for the known extreme disease effect of TCF7L2 into the opposite direction as expected by the BMI effect) and WHRonly−. The gene discussed is TCF7L2; the disease is coronary artery disorder.