F8 and breast cancer: In brief, breast cancer patients within the lowest risk category, i.e., with age younger than 70, pT1, circulating levels of FVIII within the normal range, and low levels of DD, showed significantly longer OS compared to the groups of patients at intermediate and high risk, with the related HRs being 95.6, 77.2, and 55.0, respectively (p < 0.0001).