The multi-nutrient, FC, was developed to prevent destabilization and loss of synapses, an early feature of AD,119 and several studies support this mechanism of action.36 In our study, the presynaptic protein, synaptophysin, and the post-synaptic protein, PSD-95, were used to assess synapse loss post-TBI. This evidence concerns the gene DLG4 and Alzheimer disease.