TSG-6 secretion from MSCs has previously been shown to decrease inflammation in peritonitis and corneal injury models.41,129 MSC administration in a cardiac arrest-induced global cerebral ischaemia rat model led to decreased serum pro-inflammatory cytokines and S100B concentrations and decreased expression of neutrophil elastase in the cerebral cortex.130 While TSG-6 expression in the cerebral cortex was upregulated, it was not possible to determine whether this was due to secretion from the MSCs or endogenous cells. Here, TNFAIP6 is linked to cardiac arrest.