BDNF and stroke disorder: One neurotrophin of particular interest is BDNF which promotes neuronal survival and differentiation through interaction with tyrosine kinase receptors.89 In preclinical models of stroke, IV BDNF administration reduced infarct volume, improved recovery and promoted neurogenesis.90,91 Furthermore, BDNF appears to be an important mediator in the MSC secretome preventing glutamate-induced neuronal death in vitro.