TNFAIP6 and peritonitis: TSG-6 secretion from MSCs has previously been shown to decrease inflammation in peritonitis and corneal injury models.41,129 MSC administration in a cardiac arrest-induced global cerebral ischaemia rat model led to decreased serum pro-inflammatory cytokines and S100B concentrations and decreased expression of neutrophil elastase in the cerebral cortex.130 While TSG-6 expression in the cerebral cortex was upregulated, it was not possible to determine whether this was due to secretion from the MSCs or endogenous cells.