The role of CCL5 in arbovirus-induced immunopathology remains a controversial issue, but levels of this chemokine, along with CCL2 and CCL3, were previously linked to the severity of dengue virus infections, including neurological disease and impairment of neuronal survival (Sathupan et al. 2007, Zlotnik and Yoshie 2012). This evidence concerns the gene CCL5 and dengue disease.