These included, PPBP, an antimicrobial protein with bactericidal and antifungal activity; CYBB, which is essential for the microbicidal oxidase system of phagocytes; LYZ, which encodes a component of the innate immune system that cleaves peptidoglycan bonds in the bacterial cell wall;,and CD86 and FGL2 which have been associated with severity and worse outcomes in sepsis[45, 46] These results suggest that a weaker innate immune response might predispose to bacteremia after depletion of the adaptive immune system by chemotherapy. Here, PPBP is linked to bacterial infectious disease with sepsis.