Consistent with the microarray data, mTOR inhibition promoted the expression of the NF-κB targets IL-6, IL-8, MMP1, and MMP3 (Figure 4C) but decreased the expression of the IRG TNFSF13B (Figure 4B) in TNF-treated RA-FLSs. The gene discussed is MMP1; the disease is rheumatoid arthritis.