In Alzheimer’s disease (AD; Table S1 for a full list of abbreviations), amyloid β-peptides (Aβ) and the microtubule-associated protein tau aggregate and deposit over the course of many decades to produce neuritic plaques and neurofibrillary tangles, respectively (Hyman et al., 2012). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.