Since KPT-330 was able to extend lifespan in nematodes, we sought to analyze its effect on the lifespan of a Sod1-based neurodegenerative model of amyotrophic lateral sclerosis (ALS) in flies (dsodH71Y) (Sxahin et al., 2017). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.