Lipolysis was markedly attenuate in circadian clockmutant mice hearts, and there is a potential explanation for accelerated metabolicpathologies, such as atherosclerosis which might lead to MI in patients (Tsai et al., 2010).PER2 knock-out mice had larger infarct sizes, and the cardiacPER2 have an important role in fatty acid metabolism andinflammation during myocardial ischemia and reperfusion (Bonney et al., 2013b). The gene discussed is PER2; the disease is myocardial ischemia.