PER2 and myocardial infarction: Lipolysis was markedly attenuate in circadian clockmutant mice hearts, and there is a potential explanation for accelerated metabolicpathologies, such as atherosclerosis which might lead to MI in patients (Tsai et al., 2010).PER2 knock-out mice had larger infarct sizes, and the cardiacPER2 have an important role in fatty acid metabolism andinflammation during myocardial ischemia and reperfusion (Bonney et al., 2013b).