Genetic variations in the PER2 gene are associated with abdominalobesity (Garaulet et al., 2010)and metabolic syndrome (Garcia-Rios etal., 2012) due to its part in the lipid metabolism.PER2 activation during ischemia regulates fatty acid beta-oxidationduring ischemia and inflammation during reperfusion by increasing inflammatorycytokines, metabolism and inflammation are connected, and inflammation can be aconsequence of pathologic metabolism (Bonney etal., 2013b). Here, PER2 is linked to metabolic syndrome.