COX-2 is an induciblerate-limiting enzyme for prostaglandin biosynthesis that has an essential role ininflammatory responses (Oshima and Oshima, 2013).Induction of COX-2 expression is found in more than 90% of gastric cancers and isespecially triggered by H. pylori infection (Echizen et al., 2016). The gene discussed is PTGS2; the disease is gastric cancer.