PTGS2 and neoplasm: COX-2 expression is also regulated by several cis elements in itspromoter region, such as binding sites for NF-κΒ, and by DNA promoter methylation, assuggested by several studies (Wang etal., 2005; de Maat etal., 2007; Alves etal., 2011), and its expression was associated with severalclinicopathological features of gastric carcinogenesis, such as intestinal histologicalsubtype, proximal location, tumor size and advanced clinical stage (Cheng and Fan, 2013).