The same group recently reported that Pf‐2545920, a highly specific PDE10A inhibitor, inhibits colon tumor cell growth at concentrations that increase cGMP and cAMP levels and activate PKG and PKA; and that Pf‐2545920 reduces β‐catenin‐mediated transcription of survivin, resulting in caspase activation and apoptosis 23. Here, PDE10A is linked to colonic neoplasm.