Notably, our group has demonstrated that circulating levels of Hsp10 and of BiP, both considered anti-inflammatory agents, were significantly higher in healthy controls than in patients with periodontitis, suggesting that these two cell stress proteins were either not being secreted or were being removed from the circulation in patients with periodontitis (Shamaei-Tousi et al. 2007a). The gene discussed is HSPE1; the disease is periodontitis.