McDonald and colleagues investigated the kinetics and mechanisms underlying vessel regrowth upon withdrawal of anti-angiogenic therapy and found that although two different VEGFR inhibitors, AG-013736 or AG-028262, significantly regressed tumor vasculature, they left behind empty sleeves of pericyte-covered basement membrane which functioned as a scaffold for rapid revascularization after treatment withdrawal. The gene discussed is KDR; the disease is neoplasm.