Further to suppressing tumor angiogenesis and abating the density of the vascular network, combined VEGF-A and ANGPT2 blockade normalized the structure of the blood vessels that survived in viable tumor regions and facilitated the extravasation and perivascular accumulation of activated, interferon-γ (IFNγ)-expressing CD8+ T cells [558]. This evidence concerns the gene ANGPT2 and neoplasm.