Diverse tumor-promoting pro-angiogenic CD11b+ cell types have been reported, including VEGFR-1+CD11b+ [251], Gr1+CD11b+ myeloid-derived suppressor cells (MDSC) [252], Tie-2-expressing CD11b+ monocytes (TEM) [253], and cKit+CD11b+ cells [254]. The gene discussed is TEK; the disease is neoplasm.