These tumor phenotypes were likely due to the complementary actions of ANGPT2 and VEGF-A inhibitors on the tumor microenvironment: Whereas VEGF-A blockade has more marked vascular-pruning activity, at least acutely [559], ANGPT2 blockade limits angiogenesis [551] and enforces the maturation and stabilization of the remaining vessels, making them permissive to T cell extravasation and trafficking [560, 561]. This evidence concerns the gene VEGFA and neoplasm.