Although we tested biomarkers of many aspects of the pathophysiology of ARDS including inflammation, activation of fibrotic pathways, dysregulated coagulation and a biomarker of increased intravascular volume, the top two performing biomarkers that make up the final two-marker panel are biomarkers of lung epithelial injury (RAGE) and endothelial injury (Ang-2). Here, ANGPT2 is linked to acute respiratory distress syndrome.