We now know that diseases that fall into the metabolic syndrome spectrum, such as T2DM and obesity, are associated with dysfunctional immunity and low low-grade inflammation, as shown by increased levels of proinflammatory cytokines such as TNF-α, IL-6, and chemotactic factors (e.g., CCL5 and CCL8) [6, 7, 12]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.