This locus harbors several genes including ANRIL, a long non-coding RNA gene implicated in the pathogenesis CVD and strokes, three candidate tumor suppressor genes; CDKN2A (cyclin-dependent kinase inhibitor 2A) encoding p16 protein, CDKN2B encoding p15 protein, and p14/ARF encoding p14ARF protein (35). This evidence concerns the gene CDKN2B and stroke disorder.