AKT1 and cancer: We believe that their co-infection can have critical roles in the development of these malignancies and their progression; especially, since EBV and HPVs onco-proteins share several signaling pathways, such as β-catenin, JAK/STAT/SRC, PI3k/Akt/mTOR, and/or RAS/MEK/ERK, which can enhance cancer metastatic progression via the amplification of EMT (Figure 2).