Likewise, in oral cancer samples, it has been shown that E-cadherin is downregulated in HPV-positive samples in comparison with HPV-negative ones, while, vimentin expression remained unaltered (69); herein, it is important to highlight that both E-cadherin and vimentin are important biomarkers of EMT (5). The gene discussed is CDH1; the disease is lip and oral cavity carcinoma.