It has been reported that high-fat diet and streptozotocin-induced T2DM lead to increased pancreatic miR-25 expression and decreased mRNA expression of its direct target insulin stabilizing polypyrimidine tract binding protein 1 (PTBP1) which resulted in decreased insulin translation and secretion [45] (Table 1) (Figure 2). Here, INS is linked to type 2 diabetes mellitus.