The expressional changes of these common target mRNAs could result in different diseases sharing common general pathomechanisms (e.g., NOX4 regulating oxidative stress in heart and kidney diseases, Col1a2 in myocardial fibrosis and tumor metastasis, BIM in different cancer types, etc.)(Figure 5). This evidence concerns the gene BCL2L11 and Myocardial fibrosis.