Others demonstrated that overexpression of miR-25 promoted cell proliferation, invasion and migration by directly down-regulating the tumor suppressor E3 ubiquitin ligase FBXW7 and up-regulating its substrates including G1/S-specific cyclin E1 (CCNE1) and v-myc avian myelocytomatosis viral oncogene homolog (MYC) in human GC samples and cell lines [129, 130] (Table 7) (Figure 3). The gene discussed is CCNE1; the disease is gonorrhea.