EGFR and cancer: In support of this notion, expression of dominant negative EGFR [33], blockade of EGFR kinase activity by anti-EGFR monoclonal antibody [34, 35] and treatment of non-covalent EGFR kinase inhibitors [36–38] all suppress cell proliferation and induce G1 arrest in a variety of cancer cells with only minimal cytotoxic effects.