To investigate correlation between MTBP levels and p-Erk subcellular localization in human HCC tissues, we performed immunohistochemistry (IHC) for MTBP and p-Erk using paraffin embedded non-tumor liver and HCC tissues, comprising 10 non-tumor liver, 57 primary HCC, and 36 metastatic HCC tissues. This evidence concerns the gene MAPK1 and neoplasm.