Mice injected with T18 cells (MYC+AKT+BMI1), were euthanized at day 13, exhibited less pronounced splenomegaly and contained more modest numbers of tumor cells in the bone marrow, spleen and liver, accumulated tumor cells in the kidneys but not in the thymus (Figure 3B, Supplementary Table 2B). This evidence concerns the gene BMI1 and neoplasm.