Mutations in a number of genes including PLCG1, CD28 [13], FYN [7], CTNNB1 (beta-catenin) [13], STAT3, JAK1 and TP53 [14] as well as translocations involving IRF4 [15] have also been identified in PTCL. Here, CD28 is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.