Unlike ADAM12L, ZO-1 is widely expressed by all breast cancer cell lines however, clustering analysis showed that ADAM12L and ZO-1 were highly co-expressed in 9 cell lines (HS274T, HCC1395, HS578T, HS343T, BT549, HS281T, HS606T, HS739T, HS742T) (Figure 3A). This evidence concerns the gene TJP1 and breast carcinoma.