Our data show that many of these tumor cells only express nectin-2 but not HVEM or nectin-1, indicating that these subpopulation of tumor cells are intrinsically resistant to the killing effect of the HSV-1 based oncolytic virus but remain permissive to the oncolytic effect of the HSV-2 based oncolytic virus. Here, TNFRSF14 is linked to neoplasm.