The results in Figures 1 and 4 show a dichotomous outcome for Baco-1 and FusOn-H2 when evaluated in tumor cells that only express nectin-2 but not HVEM or nectin-1, i.e., Baco-1 failed to show cell-cell spreading but was able to produce high virus yield in these tumor cells while it is almost the opposite for FusOn-H2. This evidence concerns the gene NECTIN1 and neoplasm.