RTX [5 μM] treatment induced a significant decrease of ERK mRNA expression in Jurkat cell lines after 6 h and 12 h of exposure as compared to respective control, while in patients’ cells there are not significant changes (Figure 4B) whereas when analyzing the active form of the protein by Western Blot, pERK resulted reduced in a statistically significant manner, in both Jurkat and T-ALL patient's cells by both treatments (JWH-133 and RTX) (Figure 4C, 4D). Here, MAPK1 is linked to acute lymphoblastic leukemia.