Expression level of NOTCH-1 decreases significantly only after treatment with JWH-133 in Jurkat and with RTX in T-ALL Patients (Figure 5C, 5D) while mRNA levels of p53 resulted dramatically increased by JWH-133 [100 nM] and RTX [5 μM] treatments in Jurkat cells. This evidence concerns the gene TP53 and acute lymphoblastic leukemia.