However, our findings do rule out that MYC amplification is a major genetic driver for the development of AFX or PDS since it was a very rare event, the only AFX case with MYC amplification did not show histological signs for transition into PDS, even though it was the most advanced lesion and none of the PDS cases demonstrated a MYC amplification. The gene discussed is MYC; the disease is acquired factor X deficiency.