Given the limited efficacy of EGFR-TKIs for the distinct subset of NSCLC patients with EGFR exon-20 mutations as well as the poor response to EGFR-TKI treatment apparent for NSCLC patients with HER2 exon-20 mutations, we examined the efficacy of immune-checkpoint inhibitors in these patients. This evidence concerns the gene EGFR and non-small cell lung carcinoma.