Second, CDDP resistance is caused by multiple mechanisms such as increased inactivation by reactive oxygen species, mismatch repair deficiency, increased nucleotide excision repair, increased homologous recombination proficiency and over expression of antiapoptotic BCL-2 as well as ABC transporters [36, 54–55]. This evidence concerns the gene ABCG2 and hyperinsulinemic hypoglycemia, familial, 4.