HMGCR and cirrhosis of liver: As shown in Supplementary Tables 1 and 2, FoxM1- and HMGCR-high group had a statistically significant lower rate of liver cirrhosis of liver histology than FoxM1- and/or HMGCR-low group (p = 0.0337) and FoxM1- and SREBP2-high group had a statistically significant higher PIVKA-II level than FoxM1- and/or SREBP2-low group (p = 0.0294).