In 153 cases of ER-positive breast cancer, ALCAM was expressed in 69% of Wnt5a-positive breast cancers but only 27% of Wnt5a-negative breast cancers, a statistically significant correlation between Wnt5a and ALCAM expression (Table 4) (κ = 0.444; P < 0.001). This evidence concerns the gene ALCAM and breast cancer.