EDN1 and cardiomyopathy: Another study on acute doxorubicin (DXR)-induced cardiomyopathy suggests that OLE prevents the structural, functional, and histopathological cardiac effects of chronic DXR toxicity, not by a direct antioxidant effect, but through the modulation of signalling pathways of eNOS, iNOS, ET-1, Akt, and AMPK [35].