Key role of ACOX1 in biosyntheses of eicosanoids (E series) and docosanoids (D series) further yielding specialized proresolving mediators (SPM) (resolvins, neuroprotectins, and maresins) [8, 9] is stressed along with preserved or increased ACOX1 activity in models of diabetes and metabolic syndromes. The gene discussed is ACOX1; the disease is metabolic syndrome.