Brain-derived neurotrophic factor (BDNF) seems to play a pivotal role in the prevention of brain injury, as siRNA knockdown before MSC transplantation abrogated the beneficial effects of MSC transplantation on all morphologic and functional features in the rat model of intraventricular hemorrhage including inflammatory reaction, cell death induction, myelination, astrogliosis, attenuation of posthemorrhagic hydrocephalus, and behavioral test performance [34, 122, 136]. Here, BDNF is linked to Intraventricular hemorrhage.