As shown in Figures 3A–C, MICA expression on malignant PCs, was significantly higher in MICA-129Val/Val MM patients compared to MICA-129Met/Met MM patients, thus suggesting that the increased amount of soluble MICA in the sera of MICA-129Val/Val patients could be related to an higher expression of this allelic variant. This evidence concerns the gene MICA and Miyoshi myopathy.