Interestingly, our findings indicate that the MICA-129Met/Val dimorphism is associated with: (i) differential expression of both soluble and cell surface MICA, (ii) expression levels of NKG2D on ex vivo NK cells isolated from the BM and PBL of MM patients, and (iii) the disease state. This evidence concerns the gene KLRK1 and Miyoshi myopathy.