MICA and Miyoshi myopathy: It is possible that the lowest NKG2D levels in MM patients with a MICA-129Met/Met genotype reflects the capacity of the MICA-129Met allele to more efficiently engage NKG2D and trigger NK cell activity in a cell–cell contact manner and this event appears to be independent from soluble MICA sera levels that are instead predominant in individuals carrying the MICA-129Val allele.