In regard to different castes of honeybees, after infection with E. coli, hymenoptaecin, defensin 1, abaecin, PGRPs and lysozyme 2 are detected in drones, while only hymenoptaecin, CEs and IRP30 are found in queens (Randolt et al., 2008; Albert et al., 2011; Gatschenberger et al., 2012, 2013). This evidence concerns the gene PGLYRP1 and infection.