LGALS9 and neoplasm: Further experiments performed in mouse models of leukemia (Kobayashi et al., 2010), myeloma (Kuroda et al., 2010) and hepatobiliary carcinoma (Fujita et al., 2015; Tadokoro et al., 2016) have demonstrated that treatment with recombinant Gal-9 prevents tumor progression by inducing apoptosis.